Research Studies

In an effort to pursue our mission statement: "To advance the scientific body of knowledge associated with articular and meniscal cartilage restoration, with the goal of reducing the impairment associated with loss of cartilage function," the CRCI is involved with clinical studies. These studies not only involve current applications of cartilage surgery, but also investigations of new cartilage treatment. The studies which involve new approaches are typically industry sponsored and FDA monitored. If interested in more information, see current studies below.

Current Studies

Denovo NT: Phase IV-Articular Cartilage Study. Post-marketing study of articular cartilage defects of the knee treated with DeNovo NT, Natural Tissue Graft

Depuy GCK: To examine a new patellofemoral arthroplasty. Enrollment to open in July 2007.

Neocartilage: Ongoing enrollment of phase I/II study. Investigating bioreactor generated allograft cartilage to fill focal knee cartilage defects. Please visit www.zimmer.com/z/ctl/op/global/action/l/id/9707/template/CP

Past Studies

Osiris: Phase I-Meniscus study using adult stem cells. Closed to enrollment. Two patients were enrolled at this site. One year follow-up on these two patients will be in February 2007.

Depuy SIS: Phase I-Meniscal scaffold study. Closed to enrollment. Nine patients were enrolled at this site. All nine patients are 1+ years.

Depuy CAIS: Phase I-Articular Cartilage study. fourteen patients enrolled. One year study follow-up will be in March 2007.

Neocartilage: Phase I-Articular Cartilage study using Neocartilage (living tissue grown from juvenile cartilage cells) to fill the defect. Open to enrollment.

Bionicare Registry: Registry-Electrical Pulse Stimulator System for the treatment of Osteoarthritis of the knee. Open to enrollment.

Eli Lilly and Company: Collection of Specimens from Joint Replacement Surgery for In-Vitro Osteoarthritis Research.

Patello-Femoral Knee Arthroplasty with AVON Knee System: A Clinical Investigation.

AOSSM: Comparison of the Responsiveness of the IKDC, Koos, SF-12 and Modified Cincinnati Self-Assessment Instruments in Patients Undergoing Articular Cartilage Repair.

Evaluation of the Outcome After Standard of Care Operative & Non-operative Management of the Knee

Bone Bridge Meniscal Transplantation

Fresh Articular Cartilage Allograft Transplantation

Anteriormedialization Outcomes

Conformis: Study to Evaluate the Performance of ConforMIS.

DePuy-ACL Interference Screw Fixation: Comparison-Metal vs. Bioabsorbable

Genzyme Tissue Repair-STAR (Carticel Study)

Health Outcomes in Subjects with Patellofemoral Pain: University of Indianapolis Physical Therapy Department.

Osteobiologics TruWedge vs Allograft as an HTO bone void filler